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Although radiotherapy RT decreases the incidence of locoregional recurrence in breast cancer, patients with triple-negative breast cancer TNBC have increased risk of local recurrence following breast-conserving therapy. The relationship between RT and local recurrence is unknown. Here, we tested the hypothesis that recurrence in some instances is due to the attraction of circulating tumor cells to irradiated tissues. To evaluate the effect of absolute lymphocyte count on local recurrence after RT in patients with TNBC, we analyzed radiation effects on tumor and immune cell recruitment to tissues in an orthotopic breast cancer model. Recurrent patients exhibited a prolonged low absolute lymphocyte count when compared with nonrecurrent patients following RT. Tumor cell recruitment was mitigated by inhibiting macrophage infiltration using maraviroc, an FDA-approved CCR5 receptor antagonist. Our work poses the intriguing possibility that excessive macrophage infiltration in the absence of lymphocytes promotes local recurrence after RT. This combination thus defines a high-risk group of patients with TNBC.
Sexting is sending, receiving, or forwarding sexually explicit messages, photographs, or videos, primarily between mobile phones, of oneself to others. It may also include the use of a computer or any digital device. The first published use of the term sexting was in a article in the Australian Sunday Telegraph Magazine. Sexting has become more common with the rise in camera phones and smartphones with Internet access, that can be used to send explicit photographs as well as messages. Young adults use the medium of the text message much more than any other new media to transmit messages of a sexual nature, [7] and teenagers who have unlimited text messaging plans are more likely to receive sexually explicit texts. As a result of sexting being a relatively recent practice, ethics are still being established by both those who engage in it and those who create legislation based on this concept. Whether sexting is seen as a positive or negative experience typically rests on the basis of whether or not consent was given to share the images.
